Hydroxychloroquine is predominantly an antimalarial cum 4-Aminoquinoline group of medications used in the treatment of erythrocytic plasmodial infections like malaria in the erythrocytic stage. However, many countries are using Hydroxychloroquine for Covid 19 study as well. You can buy hydroxychloroquine over the counter (200mg and 400mg) or you can buy generic hydroxychloroquine pills online at a cheap price.
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What is Hydroxychloroquine?
Sold under the brand name of Plaquenil, Hydroxychloroquine is predominantly an antimalarial medication. It also belongs to the 4-Aminoquinoline group of medications. While antimalarial medications are a kind of naturally derived anti-parasitic used to prevent malaria, 4-aminoquinoline are antimalarial medications used in the treatment of erythrocytic plasmodial infections like malaria in the erythrocytic stage. Hydroxychloroquine was first developed during World War II as a derivative of Quinacrine (now outdated antimalarial) with less severe side effects. It was approved for medical use in 1955 and had the distinction of being in the WHO's list of 'Essential Medications' because of its wide range of uses. Nowadays, the efficacy of Hydroxychloroquine for covid is under study.
What is Hydroxychloroquine used for?
It is used to treat active malaria along with being used as a prophylaxis malarial medication before going to a malaria zone. It is also used as a treatment plan for discoid lupus erythematosus and systemic lupus erythematosus (inflammatory conditions of the skin). Additionally, it is used as an effective DMARD (Disease-modifying Anti-Rheumatic Drug) against cases of rheumatoid arthritis and post-Lyme arthritis that are not responding to other forms of treatments. Hydroxychloroquine is occasionally used to treat Porphyria Cutanea Tarda, a disorder characterized by skin lesions and liver abnormalities. It is also used in some cases of Sjogren's Syndrome, an autoimmune disease leading to severe dryness. Recently, it has come into notice that Hydroxychloroquine online might be useful in treating Adult Covid-19 patients though research about it is still ongoing.
How does Hydroxychloroquine work?
Hydroxychloroquine 200mg affects the function of lysosomes in human beings as well as the malaria parasite. Lysosomes are membrane-bound cell organelles containing digestive enzymes. They break down worn-out cell parts and are used to destroy the invading microorganisms in the human body. By altering the pH of the parasites, their ability to proteolyze hemoglobin is affected, which prevents its growth and replication. Hydroxychloroquine accumulation in the human cell organelles raises their pH and helps in the cell's inflammatory response, which helps control the effects of Lupus. It also inhibits TLR-9 receptors by activating the innate immune system, and this way controls inflammation in rheumatoid arthritis.
What is the role of Hydroxychloroquine in Covid patients?
Studies have shown that this medicine can increase the endosomal PH and prevent virus-cell infusion. An increase in pH of the virus cell also prevents it from replication and thus prevents the spreading of the viral infection to some extent. It can also serve this function by interfering with the glycosylation of the ACE2 receptors. ACE 2 receptors are proteins present on the surface of many cells of the human body. They play a crucial role in regulating the blood pressure, inflammation, and wound healing capacity of the body and serving as a doorway for the Sars-Covid-12 virus, which binds to the receptors that can enter the body. By preventing glycosylation of the receptors, the binding capacity of the virus is reduced. The effective anti-inflammatory properties of Hydroxychloroquine 200mg are crucial in preventing autoimmune flare-ups and organ damage due to the virus. This quality comes in crucial during the active stage of the infection.
Which countries are currently using Hydroxychloroquine to treat the Covid virus?
Algeria, Bahrain, Belarus, Bangladesh, and Cameroon are a few names in the long list of countries using Hydroxychloroquine for Covid 19. Apart from these, China, Columbia, and the Czech Republic have played an important role in advocating this antimalarial medicine and using it actively to treat the Sars-Covid virus. According to a recent Hydroxychloroquine Covid study, Asian countries have fared much better than Western countries in treating the Covid virus and overall pandemic management because of the timely use of Hydroxychloroquine as a medication against the virus. Despite WHO not recommending this medication for Covid patients, countries like India have conducted successful trials and expanded the use of the medication in hospitals and clinical set-ups outside of laboratory trials.
How to use Hydroxychloroquine?
Hydroxychloroquine is manufactured in the form of tablets of 200mg and 400mg, respectively. They are available as white to off-white film-coated tablets with Plaquenil engraved on them. The tablets are available in bottles of 60 tablets and 100 tablets each. The prophylaxis dose of Hydroxychloroquine for malaria is 400mg once weekly for adult patients and pediatric patients greater than 31kgs in weight. That of uncomplicated malaria is 800mg administered at 6 hours, 24 hours, and 48 hours. It is not recommended for children below 31kgs, and the prophylaxis dose is supposed to be taken two weeks before leaving for the malarial belt. The doses of hydroxychloroquine for cases of Rheumatoid Arthritis are 400mg-600mg, while that for Systemic Lupus Erythematosus and Chronic Discoid Lupus Erythematosus is 200-400mg depending on the severity of the condition.
Where can I buy Hydroxychloroquine?
You can buy Hydroxychloroquine over the counter under the brand name Plaquenil but also available in Generic versions. You can buy Hydroxychloroquine tablets 200 mg (100 tablets) for around $1162. But generic tablets are much cheaper, ranging from about $100-$200 for the same number of Hydroxychloroquine pills. While Palequil is a regulated medication and you need a physician's prescription to obtain it, the generic versions are much readily available and can be obtained online. It is important to check the expiry date of the medication after you buy Hydroxychloroquine online. Also, do check for any sign of tampering and pilferage on the packaging. After being delivered, the medication should be stored in a cool dark place away from direct sunlight and far from the reach of children and pets.
What are the side effects of Hydroxychloroquine?
Headache, nausea, and vomiting are some of the common side effects associated with the use of this medication. These effects can be avoided by drinking lots of water with the medication. But dizziness, drowsiness, blurred vision, and loss of hearing can also be associated with the use of the medication. Because of this, patients are advised not to drive or operate heavy machinery after taking the tablet. Hydroxychloroquine may interact with a few other medications and cause additional side effects. So antacids should be taken 4 hours before or after taking the medication. Ampicillin should be taken around an hour before or after taking the medication. Additionally, it is important to tell your doctor about your allergies to certain things or medications before starting the medication to avoid any complications.
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